Protein Modification Reagents
Medchemexpress LLC Dm1-PEG4-DBCO | 1198.79 | C63H80ClN5O16 | 1 MG
DM1-PEG4-DBCO is a drug-linker conjugate that links the microtubule inhibitor DM1 to a DBCO-PEG4-Ahx linker for use in antibody-drug conjugate synthesis and bioorthogonal conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Drug-linker conjugate for antibody-drug conjugate synthesis.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry.
- Molecular weight 1198.79 g/mol.
- Chemical formula C63H80ClN5O16.
- Available in small vials for research use, including 1 mg and 5 mg sizes.
Medchemexpress LLC Propargyl-PEG4-NHS ester | 1428629-70-2 | 97.0% | 357.36 g·mol⁻¹ | C16H23NO8 | 100 MG
Propargyl-PEG4-NHS ester is a PEG4 linker with a terminal propargyl (alkyne) group and an N-hydroxysuccinimide (NHS) ester, designed for bioconjugation via amine coupling and click chemistry.
- Noncleavable four-unit PEG linker for spacer and solubility
- Terminal propargyl group enables copper-catalyzed azide-alkyne cycloaddition
- NHS ester provides rapid and efficient coupling to primary amines
- High purity suitable for research applications
- Molecular weight approximately 357.36 g·mol⁻¹
- Available in small research-scale package sizes
Medchemexpress LLC Mal-PEG36-NHS ester | 00-00-0 | 95.0% | C86H159N3O43 | 10MG
Mal-PEG36-NHS ester is a polyethylene glycol (PEG)-based bifunctional linker bearing a maleimide and an N-hydroxysuccinimide (NHS) activated ester. Supplied as a research-use solid, it facilitates thiol and amine conjugation for PROTAC assembly and other bioconjugation chemistries.
- Enables thiol coupling via maleimide and amine coupling via NHS ester.
- PEG36 spacer provides hydrophilicity and flexible linker length.
- High molecular weight (≈1,923 Da) for extended linker reach.
- Purity approximately 95.0% as provided by manufacturer.
- Soluble in DMSO at ~62.5 mg/mL; documented in vivo formulations exist.
- Recommended storage: -20°C for solid; low-temperature storage for solutions to preserve stability.
- Intended for research use only; not for clinical applications.
Cayman Chemical ANTIBODY DBCO-amIn 50mg
A copper-free click chemistry reagent; has been used in the synthesis of clickable fluorescent probes
Medchemexpress LLC M-PEG5-azide | 1202681-04-6 | 1 G
M-PEG5-azide is a PEG-based PROTAC linker crucial for the synthesis of PROTACs. This click chemistry reagent contains an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. It also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that have DBCO or BCN groups.
- Peg-based protac linker
- Used in protac synthesis
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC)
- Also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
CONJU PROBE LLC Methyltetrazine-PEG4-azide, 25mg | Chemical Formula: C21H30N8O5 | Molecular Weight: 474.51 | Purity: >95% by HPLC
A heterobifunctional linker functionalized with a methyltetrazine moiety for inverse electron demand Diels-Alder cycloaddition reactions and an azide for click chemistry
Medchemexpress LLC Nhpi-PEG4-C2-Pfp ester | 2101206-46-4 | >97.0% | 577.45 g/mol | C25H24F5NO9 | 1 G
NHPI-PEG4-C2-Pfp ester is a PEG4-based linker bearing an N-hydroxyphthalimide (NHPI) activated pentafluorophenyl (Pfp) ester used for bioconjugation and the synthesis of antibody-drug conjugates (ADCs).
- Used as a linker for antibody-drug conjugate synthesis.
- Contains a non-cleavable four-unit PEG spacer for improved solubility.
- Activated pentafluorophenyl ester enables efficient coupling to primary amines.
- Purity greater than 97.0% as confirmed by certificate of analysis.
- Molecular weight 577.45 g/mol and CAS number 2101206-46-4.
![eMolecules N-(Amino-PEG10)-N-bis(PEG10-azide) | Broadpharm |1519.824 | C66H134N8O30 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 500mg | 603111792](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183677.JPG-250.jpg)
eMolecules N-(Amino-PEG10)-N-bis(PEG10-azide) | Broadpharm |1519.824 | C66H134N8O30 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 500mg | 603111792
N-(Amino-PEG10)-N-bis(PEG10-azide) | Broadpharm |1519.824 | C66H134N8O30 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 500mg | 603111792
LAYSAN BIO INC Maleimide-PEG-Succinimidyl Valarate (MAL-PEG-SVA) molecular weight: 5,000., 500mg
Maleimide-PEG-SVA (Succinimidyl Valerate) is a heterobifunctional combining a maleimide group at one end of the PEG chain and a succinimidyl valerate group at the other. This unique structure allows it to react with both thiol (-SH) and amine (-NH2) groups, making it highly versatile for various bioconjugation applications.
Medchemexpress LLC Tetrazine-PEG4-amine hydrochloride | 2752945-36-9 | 99.8% | 470.95 g/mol | C20H31ClN6O5 | 5 MG
Tetrazine-PEG4-amine hydrochloride is a cleavable four-unit polyethylene glycol (PEG) linker containing a tetrazine functional group used as a click-chemistry reagent for inverse electron-demand Diels-Alder (iEDDA) reactions and in the synthesis of antibody-drug conjugates. For research use only.
- Cleavable four-unit PEG linker for ADC synthesis.
- Tetrazine group enables fast iEDDA click chemistry with TCO partners.
- Solid form with high purity (≈99.8%).
- Molecular weight 470.95 g/mol; formula C20H31ClN6O5.
- Soluble in methanol (≈250 mg/mL); may require sonication.
- Store sealed at -20°C; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
Medchemexpress LLC Methyl-PEG4-NHS ester | 622405-78-1 | MFCD11041112 | 95.0% | 333.33 | C14H23NO8 | 10G
Methyl-PEG4-NHS ester is a methyl-capped polyethylene glycol linker terminating in an N-hydroxysuccinimide (NHS) ester. It is used for amine-targeted bioconjugation and as a flexible PEG spacer in bifunctional molecules, enabling efficient formation of stable amide bonds and improved solubility.
- Provides an NHS ester for rapid conjugation to primary amines.
- Methyl-capped PEG4 spacer increases solubility and linker flexibility.
- Suitable for PROTAC synthesis and general bioconjugation applications.
- Molecular weight 333.33 and molecular formula C14H23NO8.
- CAS number 622405-78-1 and MFCD11041112 for reference.
- Typical purity around 95.0% and available in multiple pack sizes.
Medchemexpress LLC DSPE-PEG carboxylic acid (sodium) | 1403744-37-5 | 98.0% | (C2H4O)nC45H86NO12P.Na | 25 MG
DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used in the preparation of drug delivery nanoparticles. It is capable of extending the blood circulation time and stability of liposomes, while also improving the targeting ability and cellular uptake efficiency of nanoparticles.
- Used in the preparation of drug delivery nanoparticles
- Prolongs the blood circulation time and stability of liposomes
- Enhances the targeting ability of nanoparticles
- Improves cellular uptake efficiency of nanoparticles
![eMolecules 2354291-37-3 | Gly-PEG3-endo-BCN | Broadpharm453.580 | C23H39N3O6 | 0.000 | NCC(=O)NCCCOCCOCCOCCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 550804569](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183536.JPG-250.jpg)
eMolecules 2354291-37-3 | Gly-PEG3-endo-BCN | Broadpharm453.580 | C23H39N3O6 | 0.000 | NCC(=O)NCCCOCCOCCOCCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 550804569
Gly-PEG3-endo-BCN | Broadpharm | 2354291-37-3453.580 | C23H39N3O6 | 0.000 | NCC(=O)NCCCOCCOCCOCCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 550804569
![eMolecules 16-(Azide-PEG3-ethylcarbamoyl)pentadecanoic-t-butyl ester | Broadpharm |542.762 | C28H54N4O6 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784454990](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502473326.JPG-250.jpg)
eMolecules 16-(Azide-PEG3-ethylcarbamoyl)pentadecanoic-t-butyl ester | Broadpharm |542.762 | C28H54N4O6 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784454990
16-(Azide-PEG3-ethylcarbamoyl)pentadecanoic-t-butyl ester | Broadpharm |542.762 | C28H54N4O6 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784454990